George Coukos is a pioneer in the development, delivery and evaluation of personalized, cell-based immunotherapies. In Lausanne, George Coukos built the Department of Oncology and the Lausanne Ludwig Branch. He founded and directs the Human Integrated Tumor Immunology Discovery Engine (Hi-TIDe), an innovative research group of structured team science, oriented towards targeted human discovery and the development and testing of novel and rational T-cell therapy approaches for solid tumors. His most current research efforts focus on (a) identifying T cells recognizing tumor-specific neoantigens and leveraging them for therapy, and (b) systems biology and systems engineering of neoantigen specific T cells, as a means to overcome the deregulation of T cells in the TME, and thus develop curative individualized T cell therapies for solid tumors, with the ultimate goal of translating basic discoveries to the clinic.