I have a special interest in rare diseases as indications for hematopoietic stem cell transplantation (HCT), particularly lysosomal storage diseases, and in finding strategies to get better disease control in malignant diseases. My research focuses on developing advanced therapies from cord blood to target blood disorders at the cellular level, including dendritic cell vaccines. My lab is also creating mathematical models that can help us predict how a young person’s immune system will respond to receiving such treatments. Additionally, I am interested in designing a predictable low-toxicity conditioning regimen using pharmacokinetic/pharmacodynamic (PK/PD)-models (eg, anti-thymocyte globuline [ATG], fludarabine, clofarabine) to better predict immune reconstitution, which is necessary for the optimal effect of vaccines. At MSK, I also serve as Director of the Immune Discovery & Modeling Service (IDMS) core facility (7FTE, 3 Fellows).